- For Lab, for Research and Development (R&D) or manufacturing purposes only
- Supporting life science research and development and production
- HealthyFindsBio is an innovative life science raw material manufacturing and custom synthesis company. We are committed to providing high quality products to improve human health and achieve sustainable growth for the company
- The company specializes in the production and research of various nutritional and pharmaceutical ingredients, and we pride ourselves on achieving delivery goals that are difficult for other companies to achieve
- Our research and development resources and production facilities as well as analytical instruments are advanced and leading-edge, allowing us to achieve production and precision delivery in the milligram to tonnage range, in compliance with ISO9001 and GMP standards
Product name | SLU-PP-332 |
Other name | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
CAS No. | 303760-60-3 |
Molecular formula | C18H14N2O2 |
Molecular weight | 290.32 |
Purity | 99% |
Appearance | White or off-white powder |
Packing | 1kg/bag, 25kg/barrel |
Application | Dietary Supplement Raw Material |
Product introduction
SLU-PP-332 is a novel small molecule compound that acts as a perifollicle estrogen receptor (ERR) agonist, primarily targeting ERRα, ERRβ, and ERRγ, with the strongest activation effect on ERRα (EC₅₀=98 nM). This compound activates the ERR signaling pathway by mimicking the metabolic regulation mechanisms of exercise, thereby modulating energy metabolism, mitochondrial function, and muscle endurance.
Feature
(1)Mechanism of action: activate ERRα/β/γ, upregulate fatty acid oxidation (FAO) and mitochondrial respiration related genes, promote fat breakdown for energy supply, reduce fat accumulation, enhance skeletal muscle mitochondrial function, improve oxidative capacity and endurance, similar to the effect of aerobic training.
(2)Bioactivity: a) Animal model effects: Obese mice: after 28 days of medication, body weight decreased by 12%, and liver fat, cholesterol, and triglycerides were significantly reduced; normal mice: running time increased by 70%, distance increased by 45%, without affecting appetite or voluntary movement. b) Safety: no serious side effects were observed in preclinical studies.
(3)Physical and chemical properties: white to white solid, soluble in DMSO (75 mg/mL) and ethanol, insoluble in water; should be stored in the dark.
Applications
SLU-PP-332 achieves fat loss and blood glucose regulation by promoting fat oxidation and improving insulin sensitivity; it improves non-alcoholic fatty liver disease (NAFLD), reducing liver fat content; provides metabolic support for individuals who cannot exercise, maintaining muscle mass and function; reduces muscle loss during the fat loss process; and has broad prospects in the areas of fat loss, endurance enhancement, and metabolic improvement.